What is Cytomel and what is it used for?
Cytomel is a prescription medicine used to treat the symptoms of low thyroid hormone levels (hypothyroidism) and an overactive thyroid gland (non-toxic goiter), myxedema and myxedema coma. Cytomel can be used alone or in combination with other medicines. Cytomel belongs to a group of medicines called antithyroid medicines.
What are the possible side effects of Cytomel?
Cytomel can cause serious side effects, such as:
- Headache,
- Irritability,
- Difficulty sleeping,
- Nervousness,
- Excessive sweating,
- Heat intolerance,
- diarrhoea and
- changes in menstruation
If you experience any of the symptoms listed above, contact your doctor immediately. These are not all the possible side effects of Cytomel. Ask your doctor or pharmacist for more information. Ask your doctor about side effects. You can report side effects to the FDA at 1-800-FDA-1088.
RECORD
Thyroid hormone preparations are natural or synthetic preparations containing tetraiodothyronine sodium (T4, levothyroxine) or triiodothyronine sodium (T3, liothyronine) or both. T4 and T3 are formed in the human thyroid gland by iodination and binding of the amino acid tyrosine. T4 has four iodine atoms and is formed by binding to two molecules of diiodothyrosine (DIT). T3 has three iodine atoms and is formed by the fusion of one molecule of DIT with one molecule of monoiodotyrosine (MIT). Both hormones are stored in the thyroid colloid as thyroglobulin .
Thyroid hormone preparations fall into two categories: (1) natural hormone preparations derived from the thyroid gland of animals and (2) synthetic preparations. Natural preparations include dried thyroid glands and thyroglobulin. Dried thyroid glands are obtained from domestic animals used by humans (bovine or porcine thyroid glands) and thyroglobulin is obtained from porcine thyroid glands. The United States Pharmacopoeia (USP) has standardised the total iodine content of natural products. Thyroid contains a minimum (NLT) of 0,17 % and a maximum (NMT) of 0,23 % of iodine and thyroglobulin contains a minimum (NLT) of 0,7 % of organically bound iodine. Iodine content is only an indirect indicator of the biological activity of hormones.
Cytomel (liothyronine sodium) tablets contain liothyronine (L-triiodothyronine or LT3), a synthetic form of the natural thyroid hormone, in the form of a sodium salt.
INDICATIONS
Thyroid hormone preparations:
Replacement or adjunctive therapy in patients with thyroid insufficiency of any aetiology, with the exception of transient hypothyroidism in the recovery phase after subacute thyroiditis. This category includes cretinism, myxedema and normal hypothyroidism in patients of any age (children, adults, elderly) or condition (including pregnancy); primary hypothyroidism due to primary hypothyroidism, primary atrophy, partial or total absence of the thyroid gland, or due to surgery, radiation or medical treatment, with or without hernias; secondary (pituitary) or tertiary (hypothalamic) hypothyroidism (see section “Hypothyroidism in the general population”). thyroid disorders). WARNINGS).
As a thyroid hormone (TSH) suppressant in the pituitary gland for the treatment or prophylaxis of a variety of thyroid-related disorders such as thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto’s disease) and multiple thyroid nodules.
As a diagnostic aid in suppression studies to differentiate between suspected moderate hyperthyroidism or autonomous thyroid disease. Cytomel (lithironine sodium salt) tablets may be used in patients allergic to desiccated thyroid gland or thyroid extract from pork or beef.
Effects of the medicine
The effects of Cytomel are generally the same irrespective of the indication, whether it is the treatment of hypothyroidism or the improvement of fat breakdown during exercise. In both cases, the hormone acts in the same way as a direct copy of the T3 hormone. Regardless of the primary purpose of use, both should have the ability to burn fat. Now the hypothyroid patient’s metabolism should function better and help him or her to break down fat. Often this is welcome, as the person has probably accumulated enough fat due to thyroid disease. Fat loss is simply accelerated to increase performance.
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MECHANISM OF ACTION OF CYTOMEL IN THE BODY
The action of any drug is based on the properties of the active ingredient. In the case of a fat burner like Cytomel, it should be noted that triiodothyronine T3, a hormone produced by the thyroid gland, was used in its production. It was synthesized recently and has been rapidly put into use. Cytomel can speed up the body’s metabolism and help athletes who want to get rid of excess weight. The product increases cellular activity so that proteins, fats and carbohydrates are metabolized very quickly.
Before competition, triiodothyronine-based Cytomel is used to break down excess fat stores and fluid while the diet remains unchanged. The drug is often combined with clenbuterol to enhance the effect, resulting in a significant effect. The muscles of the athlete become more attractive and better shaped. The drug can also be used in combination with anabolic steroids to start building muscle mass while reducing fat stores.
The specific properties of the drug are:
- Improvement of the athlete’s well-being during the course;
- Removal of fatty tissue;
- Differentiation of muscle tissue.
Pharmacokinetics
When taken orally, levothyroxine is absorbed almost exclusively from the upper part of the small intestine. Up to 80% of the administered dose is absorbed. Ingestion of food decreases absorption of levothyroxine. Serum Cmax is reached 6 hours after ingestion. After absorption, more than 99% of the drug is bound to serum proteins. In various tissues, levothyroxine is monodialyzed to triiodothyronine and inactive products. Thyroid hormones are mainly degraded in the liver, kidneys, brain, and muscles. Small amounts are deaminated and decarboxylated and conjugated to sulfuric and glucuronic acids (in the liver). Metabolites are excreted in urine and bile. T1/2 is 6-8 days.